In April, both the National Institutes of Health (NIH) and the U.S. Food and Drug Administration (FDA) announced new initiatives to expand innovative, human-based science while reducing animal use in research. According to NIH Director Dr. Jay Bhattacharya, “This human-based approach will accelerate innovation, improve healthcare outcomes, and deliver life-changing treatments. It marks a critical leap forward for science, public trust, and patient care.” I encourage all Minnesota research labs to be leaders in this national effort to advance science using new, emerging, and humane technologies.